Dr. Chris Thompson, MD, Professor of Medicine at Harvard Medical School, Chief of Interventional Gastroenterology at Mass General Brigham in Boston, and Co-Director of the Center for Weight Management and Wellness, is a world-renowned expert on gastroenterology, metabolism, nutrition, and obesity medicine. He explains how your GI tract regulates hunger, fullness, and blood sugar, as well as the gut microbiome, metabolic health, and weight loss. We also discuss common GI tract issues and which particular tests or interventions are actually useful. We discuss both GLP-1 medications and non-GLP-1 approaches to weight loss. Given that gut health is vital to all the organs of the body, overall health, and longevity, our discussion ought to be of interest and practical value to everyone, including, of course, those struggling with gut health or weight loss challenges.

Show notes: https://go.hubermanlab.com/moMYULJ

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Timestamps
00:00:00 Dr. Chris Thompson
00:02:16 Digestive Tract, Gut Hormones & Nutrient Absorption
00:08:06 Colon Microbiome & Colon Cancer Screening
00:11:13 Sponsors: LMNT & Lingo
00:13:40 Swallowing Problems & Zenker’s Diverticula
00:16:08 Bowel Movements & Constipation
00:18:28 Fiber, Resistant Starch & the Gut Barrier
00:21:50 Intermittent Fasting & the Gut Microbiome
00:23:38 Fermented Foods, Microbial Diversity & Butyrate
00:27:12 H. pylori, Stress & Stomach Ulcers
00:30:20 GLP-1 Medications: Benefits & Limitations
00:33:42 Lower GLP-1 Doses, Weight Regain & Muscle Loss
00:37:35 GLP-1 Side Effects, Food Noise & Apathy
00:39:49 Bariatric Surgery & Medical Innovation
00:46:07 Sponsor: AG1
00:47:44 Hunger & Satiety: Ghrelin, CCK, GIP & GLP-1
00:50:01 Retatrutide & Combining Hormonal Targets
00:52:55 Ultra-Processed Foods, Overeating & Leptin
00:55:32 Incretin Discovery, Exendin-4 & the Gila Monster
00:59:35 Endoscopic Ultrasound & Pancreatic Biopsy
01:07:40 Early Metabolic Markers, CGMs & Fasting Insulin
01:13:06 Insulin Resistance & Metabolic Flexibility
01:15:53 Sponsor: Function
01:17:35 Patient Data, Screening & Treatment Adoption
01:26:31 AI, Robotics & Improving Procedures
01:29:27 Choosing a Surgeon & Measuring Procedure Quality
01:35:29 Image Guidance & Hyperspectral Imaging
01:37:19 Sponsor: Our Place
01:38:56 Diagnostics & Targeted Metabolic Treatments
01:42:45 Gastric Bypass, Foregut Exclusion & Diabetes
01:47:59 Duodenal Liners & Mucosal Resurfacing Research
01:52:58 Gut Permeability, Inflammation & Fatty Liver
01:59:39 Artificial Sweeteners, Fructose, Fats & Omega-3s
02:05:00 Resistance Training, Zone 2 Cardio & Intervals
02:06:31 Weight Set Point & Metabolic Adaptation
02:08:13 Endoscopic Sleeve Gastroplasty & Fundus Ablation
02:10:30 Magnetic Intestinal Connections & Combined Treatments
02:16:52 GLP-1 Gene Therapy Research
02:22:13 Innovation, Problem Solving & Teamwork
02:25:58 Zero-Cost Support, Sponsors & Neural Network Newsletter

#hubermanlab #science #guthealth

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

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For early access, all references, and additional nuances, check out the associated StayCurious Metabolism newsletter https://staycuriousmetabolism.substack.com/p/reset-your-vagus-nerve-to-control?r=40ekz2

Get 10% off your Pulsetto FIT here: https://pulsetto.tech/pages/StayCurious or use my coupon code: StayCurious.

It’s completely risk-free with a 30-day money-back guarantee, so you can test it and see how your body responds.

Chapters
0:00 – Reset Your Vagus Nerve to Control Gut Inflammation
1:38 – The Takes Are Greater Than I Realized
3:06 – The Gut Health Study That Hit Close to Home
5:52 – What The SUMOylation?
6:54 – Quick Summary of Main Points So Far
8:18 –Stimulating the Vagus Nerve Lowers Inflammation in Humans
11:04 – The Wiring Diagram
13:13 – Levers and Tools You Can Use Today

Description
What if stress isn’t merely “in your head,” but is physically wired into inflammation? In this video, I explore the emerging science of the vagus nerve, inflammation, gut health, and autoimmune disease. We start with research showing how stress worsened experimental colitis in mice, and how electrical vagus nerve stimulation reversed inflammatory changes.

But this isn’t only mouse biology. We examine a randomized, double-blind human trial of vagus nerve stimulation in rheumatoid arthritis, including evidence of clinical improvement and a signal for reduced bone erosion.

Finally, we get practical: slow exhale-focused breathing, stress reduction, and non-invasive transcutaneous vagus nerve stimulation, including my personal experience with a cervical vagus nerve stimulation device. The larger lesson is that the nervous and immune systems aren’t separate worlds, they’re in constant communication.

#VagusNerve #VagusNerveStimulation #Inflammation #ChronicInflammation #GutHealth #GutBrainAxis #BrainGutConnection #NervousSystem #ParasympatheticNervousSystem #AutonomicNervousSystem #AutoimmuneDisease #Autoimmunity #UlcerativeColitis #CrohnsDisease #IBD #InflammatoryBowelDisease #RheumatoidArthritis #Stress #StressManagement #StressRelief #Breathwork #BreathingExercises #CyclicSighing #HRV #HeartRateVariability #tVNS #BioelectronicMedicine #Neuromodulation #Immunology #ImmuneSystem #GutInflammation #BrainHealth #MentalHealth #Anxiety #Sleep #Insomnia #Cortisol #HealthScience #MedicalResearch #Science #MetabolicHealth #Longevity #Healthspan #Biohacking #WellnessScience #MindBodyConnection #StayCurious #StayCuriousMetabolism #Pulsetto #vagaltone

Disclaimer: The content presented in this video is for informational and educational purposes only and should not be construed as medical advice. Any decisions regarding your health should be made in consultation with your personal healthcare provider, who can consider your individual circumstances and medical history. This content contains a partnership message from Pulsetto. Pulsetto is a general wellness product intended to support a healthy lifestyle. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition. As with all of my partnerships, I only work with companies that meet a strict set of criteria. Specifically, the product or service must provide a genuine solution to a real problem faced by my audience, operate to the highest standards of quality and ethics, and be something that I personally use or would feel comfortable recommending to family and close friends. While I am compensated for partnerships, my opinions remain my own, and I strive to maintain the same standards of honesty, transparency, and scientific rigor regardless of whether content is sponsored or unsponsored. You can learn more about all partnerships at nicknorwitz.com.

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