{"id":4035,"date":"2026-10-28T07:00:39","date_gmt":"2026-10-28T07:00:39","guid":{"rendered":"https:\/\/optimalfitness-health.com\/?p=4035"},"modified":"2026-10-28T07:00:39","modified_gmt":"2026-10-28T07:00:39","slug":"the-new-weight-loss-drug-that-makes-ozempic-look-like-the-beginning","status":"publish","type":"post","link":"https:\/\/optimalfitness-health.com\/?p=4035","title":{"rendered":"The New Weight Loss Drug That Makes Ozempic Look Like the Beginning"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"480\" height=\"270\" src=\"\/\/www.youtube.com\/embed\/HkIZ8LK_6TA\" frameborder=\"0\" allowfullscreen><\/iframe><\/p>\n<p>In this video, I&#8217;m breaking down the most exciting<br \/>\ndrug in metabolic medicine right now \u2014retatrutide,<br \/>\nEli Lilly&#8217;s investigational triple agonist that just<br \/>\nreported Phase 3 results that stopped me in my tracks.<\/p>\n<p>As a double board-certified endocrinologist, I&#8217;ve<br \/>\nbeen following this drug closely \u2014 and the TRIUMPH-1 and TRANSCEND data are unlike anything I&#8217;ve seen in this class.<\/p>\n<p>\ud83d\udcca WHAT THE DATA SHOWS:<br \/>\n\u25b8 70 lbs lost (28.3% body weight) at 80 weeks on<br \/>\n  the highest dose<br \/>\n\u25b8 Up to 30% weight loss at 2 years in severe obesity<br \/>\n\u25b8 65% of patients dropped below a BMI of 30<br \/>\n\u25b8 A1c reductions of up to 2.0% in Type 2 diabetes<br \/>\n\u25b8 46% of diabetic patients achieved a completely<br \/>\n  normal A1c<\/p>\n<p>\ud83d\udc8a WHAT MAKES RETATRUTIDE DIFFERENT:<br \/>\nSemaglutide (Ozempic, Wegovy) activates 1 receptor.<br \/>\nTirzepatide (Mounjaro, Zepbound) activates 2.<br \/>\nRetatrutide activates 3 \u2014 GLP-1, GIP, AND glucagon \u2014<br \/>\nmaking it the most potent agent ever studied in this class.<\/p>\n<p>\u26a0\ufe0f IMPORTANT: Retatrutide is not yet FDA approved.<br \/>\nA regulatory submission is anticipated in 2026.<br \/>\nThis video is for educational purposes only and does<br \/>\nnot constitute medical advice.<\/p>\n<p>\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<br \/>\n\ud83d\udd14 SUBSCRIBE for weekly science-backed updates on<br \/>\nhormones, metabolism, GLP-1 medications, and<br \/>\nperimenopause health from a practicing endocrinologist.<br \/>\n\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n<p>\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<br \/>\n\ud83d\udc69\u200d\u2695\ufe0f ABOUT DR. ALESSIA ROEHNELT<br \/>\nDouble board-certified in Endocrinology and Internal<br \/>\nMedicine. Practicing at EndoHealth MD in Westfield, NJ<br \/>\nwith telehealth across NJ, NY, and FL.<\/p>\n<p>\ud83d\udccd endohealthmedical.com<br \/>\n\ud83d\udcf1 Instagram &amp; TikTok: @endohealthdoc<br \/>\n\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n<p>CHAPTERS:<br \/>\n0:00 Hook \u2014 The drug changing everything<br \/>\n0:15 What is retatrutide?<br \/>\n0:30 How it differs from semaglutide &amp; tirzepatide<br \/>\n1:00 TRIUMPH-1 Phase 3 weight loss results<br \/>\n1:45 TRANSCEND \u2014 A1c and diabetes data<br \/>\n2:30 Who this drug may be for<br \/>\n3:00 When to expect FDA approval<\/p>\n<p>\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<br \/>\nDISCLAIMER: This video is intended for educational<br \/>\npurposes only and does not constitute medical advice.<br \/>\nAlways consult a licensed healthcare provider before<br \/>\nstarting, stopping, or adjusting any medication.<\/p>\n<p>#retatrutide #GLP1 #weightloss #Ozempic #tirzepatide<br \/>\n#semaglutide #Mounjaro #Wegovy #metabolichealth<br \/>\n#endocrinology #obesity #type2diabetes #hormonehealth<br \/>\n#perimenopause #insulinresistance #endohealthdoc<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this video, I&#8217;m breaking down the most exciting drug in metabolic medicine right now \u2014retatrutide, Eli Lilly&#8217;s investigational triple [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":4036,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4035","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.6 - 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